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microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer

Research output: Research - peer-reviewJournal article

Stephanie Geisler Crone, Anders Jacobsen, Birgitte Federspiel, Linda Bardram, Anders Krogh, Anders H. Lund, Lennart Friis-Hansen

Gastric cancer is the second most common cause of cancer-related death in the world. Inflammatory signals originating from gastric cancer cells are important for recruiting inflammatory cells and regulation of metastasis of gastric cancer. Several microRNAs (miRNA) have been shown to be involved in development and progression of gastric cancer. miRNA-146a (miR-146a) is a modulator of inflammatory signals, but little is known about its importance in gastric cancer. We therefore wanted to identify targets of miR-146a in gastric cancer and examine its biological roles.
Original languageEnglish
JournalMolecular Cancer
Volume11
Issue number71
Pages (from-to)71
Number of pages31
ISSN1476-4598
DOIs
StatePublished - 2012

    Research areas

  • Animals, CARD Signaling Adaptor Proteins, Cell Line, Tumor, Cytokines, Disease Models, Animal, Enzyme Activation, Gene Expression Regulation, Neoplastic, Humans, Mice, Mice, Knockout, MicroRNAs, Monocytes, NF-kappa B, Proteins, Receptors, G-Protein-Coupled, Signal Transduction, Stomach Neoplasms

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