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2009-07-23

Paper in Toxicological Sciences

Eivind Valen , Albin Sandelin and collaborators published a paper in Toxicological Sciences on the interaction between aryl hydrocarbon receptor and estrogen receptor alpha at human promoters.

 This is the first comprehensive study on the interaction between ERa and AHR – using promoter tiling arrays and computational analyses on the detected regions - , and shows that dioxin induces the recruitment of ERalpha to AHR target genes but also that AHR is recruited to estrogen responsive regions in a gene-specific manner, suggesting that AHR utilizes both of these mechanisms to modulate estrogen dependent signaling.

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